Prof. Girolamo Cirrincione

He graduated in chemistry from the University of Palermo. After completing one year of military service, he did his postdoctoral fellowship at the Medicinal Chemistry Department of the University of Palermo from May 1975 to March 1976; from April 1976 to October 1981, he was a research fellow and from November 1981 to October 1994 an associate professor of medicinal chemistry at the same institution. Since November 1994, he has been a full professor of medicinal chemistry at the University of Palermo. He has obtained CNR-NATO Fellowships (September 1982–May 1983, July–August 1986, July–September 1989) and British Council Fellowship (August 1984), from the School of Chemical Sciences of the University of East Anglia (Norwich, UK). He has served as the director of the Istituto Farmacochimico (March 1995–June 1999) and director of the Dipartimento Farmacochimico Toss. Biol. (July 1999–December 2004 and July 2005–Dec. 2010). He is responsible for ERASMUS exchanges of the Faculty of Pharmacy of the University of Palermo; for the research sector ‘Synthetic Analogues of Natural Structure of Biological Interest’ of the ICTPN-CNR in a scientific capacity (January 1994–December 1998). He was Coordinator of the PhD course in Medicinal Chemistry (May 2009–October 2013). He was Dean of the Faculty of Pharmacy (November 2010–December 2013) He is member of the Drug Discovery Committee of the European Organization for Research and Treatment of Cancer, the Societa` Chimica Italiana, and the International Society of Heterocyclic Chemistry (which he has also served in the capacity of vice-president for the period 2004–05). He is President of the Medicinal Chemistry Division of the Società Chimica Italiana (January 2013–December 2015) He is a scientific editor of the journal ARKIVOC.

The research activity is devoted to the design, synthesis, reactivity studies, biological evaluation and SAR studies of nitrogen heterocyclic systems of pharmaceutical interest.

Invited Lectures

Selective Ligands for Actinide-Lanthanide Separations
Design, Synthesis, And Pharmacological Properties Of New Cb₂ Cannabinoid Receptor Ligands
Novel Rearrangements in Targeted Synthesis of Natural Compound Analogs
Nef-Isocyanide Adducts as key Intermediates for Synthesis of Heterocyclic Compounds
Multicomponent 1,3-Dipolar Cycloadditions of Stabilized Azomethine Ylides
Discovering new applications of chiral N-sulfinyl imines in heterocyclic chemistry
Aliphatic Nitrocompounds as Strategic Sources of Heterocycles
Synthetic Strategies for New Pyrazoles of Potential Biological Activities
Enaminones in the synthesis of heterocyclic systems. [2+2] Cycloadditions, ring expansion reactions and other transformations
Design, synthesis and pharmacological properties of new thiazole and thiadiazole derivatives
Cultivating over thirty years the passion to build heterocycles from 1,2-diaza-1,3-dienes
[1,4]Thiazino[3,4-c][1,2,4]oxadiazol-3-ones: an examination of their reactivity and of their biological profile
Effective Conversion of Carbohydrate Molecules to Nitrogen-containing Heterocyclic Derivatives
Recent Advances in Appel Salt Chemistry
Heterocyclic compounds in the design of biodegradable polymers
Synthesis and study of some triazolo Isoxazole heterocyclic Compounds
Three different approaches to target the T315I mutation: ATP-competitive, ATP-non-competitive and 14-3-3 inhibitors
Tetrapyrrolic macrocycles: Synthetic features and potential applications
Reactivity of alpha-halogen substituted pyridinium ylides.
Benzopyran building blocks: herald of hope for multitarget drug discovery
A new general 3CR leading to 1,4,5-trisubstituted-1,2,3-triazoless
Marine alkaloid nortopsentin analogues inhibitors of cyclin-dependent kinase 1 (CDK1)